Trifluoroacetic acid → Phenyl pyrrolidine-3-carboxylate

HRID 1053522Notes

Reaction equation

HRID 1053522 reaction equation
N1CCCC1C(OC1C=CC=CC=1)=O.C(O)(C(F)(F)F)=O.[N:22]1(C(OC(C)(C)C)=O)[CH2:26][CH2:25][CH:24]([C:27]([O:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[O:28])[CH2:23]1>>[NH:22]1[CH2:26][CH2:25][CH:24]([C:27]([O:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[O:28])[CH2:23]1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 15598566Phenyl pyrrolidine-2-carboxylateHCID 898737321-tert-Butyl 3-phenyl pyrrolidine-1,3-dicarboxylate

Product 1

HCID 69577543Phenyl pyrrolidine-3-carboxylate

Procedure

The compound 25 was prepared according to the method described for compound 23 employing TFA (0.66 mL, 8.58 mmol) and compound 24 (500 mg, 1.71 mmol) to give white solid compound. The compound was used without further purification after solvent removal.

Workup

  1. customto give white solid compound
  2. customThe compound was used without further purification
  3. customafter solvent removal

Sources & evidence

ORD record
ord-0f001729c14f4ad6807ebbd1657c1e36
Source dataset
uspto-grants-2016_07
Patent number
US09393306B2

Reaction notes

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