Trifluoroacetic acid → 1-(3-Phenoxypropyl)piperazine

HRID 1053525Notes

Reaction equation

HRID 1053525 reaction equation
N1CCCC1C(OC1C=CC=CC=1)=O.C(O)(C(F)(F)F)=O.[O:22]([CH2:29][CH2:30][CH2:31][N:32]1[CH2:37][CH2:36][N:35](C(OC(C)(C)C)=O)[CH2:34][CH2:33]1)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[O:22]([CH2:29][CH2:30][CH2:31][N:32]1[CH2:33][CH2:34][NH:35][CH2:36][CH2:37]1)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 15598566Phenyl pyrrolidine-2-carboxylateHCID 131736284tert-Butyl 4-(3-phenoxypropyl)piperazine-1-carboxylate

Product 1

HCID 27603511-(3-Phenoxypropyl)piperazine

Procedure

The compound 30 was prepared according to the method described for compound 23 employing TFA (6 mL) and compound 28 (550 mg, 1.72 mmol) to give white solid compound. The compound was used without further purification after solvent removal.

Workup

  1. customto give white solid compound
  2. customThe compound was used without further purification
  3. customafter solvent removal

Sources & evidence

ORD record
ord-7469df9e5e3040b4a2be972c9df7fe97
Source dataset
uspto-grants-2016_07
Patent number
US09393306B2

Reaction notes

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