反应详情

温度

27.5 °C

In a four neck round bottom flask, charged methanol (2900 ml), 2-([(5S)-2-Oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione (290 g), and 40% aqueous methylamine (265 g) at 25 to 30° C. Reaction mass is stirred for 1 h at 25 to 30° C. and then heated to 60 to 65° C., and maintained at same temperature for 4 h. Reaction mixture then cooled to 25 to 30° C. and added conc. hydrochloric acid (290 ml, pH should be 1 to 2) and stirred for 30 minutes. Obtained solid is filtered off and washed by chilled methanol (290 ml).

1. customReaction mass
2. temperatureheated to 60 to 65° C.
3. temperaturemaintained at same temperature for 4 h
4. customReaction mixture
5. temperaturethen cooled to 25 to 30° C.
6. stirringstirred for 30 minutes
7. customObtained solid
8. filtrationis filtered off
9. washwashed
10. temperatureby chilled methanol (290 ml)