反应详情

温度

130 °C

To a stirring suspension of ethyl 5-chloro-2-nitrobenzoate (15 g, 65.3 mmol) and K2CO3 (13.54 g, 98 mmol) in DMF (5 ml) was added phenol (6.76 g, 71.9 mmol). Reaction mixture was heated at 130° C. for 16 h. Reaction mixture was diluted with water and extracted with EtOAc. The organic layer was separated and distilled out to get crude product which was column purified using 10% EtOAC in hexane to get the titled compound in 36% yield.

1. customReaction mixture
2. customReaction mixture
3. extractionextracted with EtOAc
4. customThe organic layer was separated
5. distillationdistilled out
6. customto get crude product which
7. custompurified