Hydrochloric Acid → HCID 118590414, compound

HRID 1054467Notes

Reaction equation

HRID 1054467 reaction equation
[ClH:1].C([S@@]([N:8]1[CH2:12][CH2:11][CH2:10][CH:9]1[C:13]1[CH:18]=[C:17]([F:19])[CH:16]=[CH:15][C:14]=1[O:20][C@@H:21]1[CH2:25][CH2:24][O:23][CH2:22]1)=O)(C)(C)C>O1CCOCC1>[ClH:1].[F:19][C:17]1[CH:16]=[CH:15][C:14]([O:20][C@@H:21]2[CH2:25][CH2:24][O:23][CH2:22]2)=[C:13]([CH:9]2[CH2:10][CH2:11][CH2:12][NH:8]2)[CH:18]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 118590475HCID 118590475, compound

Product 1

HCID 118590414HCID 118590414, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

4M HCl solution (in Dioxane) (20 mL) was added to stirred solution of 1-((S)-tert-butylsulfinyl)-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidine (4.1 g, 11.54 mmol) in Dioxane (25 mL) and stirring was continued at 20-35° C. for 4 h. After which the reaction mixture was concentrated under reduced pressure to afford the crude product. The crude product was purified by washing with diethyl ether to afford 3.2 g of the title compound as a white solid. MS (ESI): 288.2 (M+H).

Workup

  1. concentrationAfter which the reaction mixture was concentrated under reduced pressure
  2. customto afford the crude product
  3. customThe crude product was purified
  4. washby washing with diethyl ether

Sources & evidence

ORD record
ord-c610d1d92e6746aeba2e6787667eca90
Source dataset
uspto-grants-2016_07
Patent number
US09394305B2

Reaction notes

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