HCID 72705474, compound → HCID 178427934, compound

HRID 1054996Notes

Reaction equation

HRID 1054996 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([Cl:33])[C:5]2[N:6]([N:9]=[C:10]([CH2:12][CH2:13][C:14]3[N:18]=[C:17]([N:19]4[CH2:23][CH2:22][CH2:21][CH2:20]4)[N:16](CC4C=CC(OC)=CC=4)[N:15]=3)[N:11]=2)[C:7]=1[CH3:8]>FC(F)(F)C(O)=O>[Cl:1][C:2]1[CH:3]=[C:4]([Cl:33])[C:5]2[N:6]([N:9]=[C:10]([CH2:12][CH2:13][C:14]3[N:18]=[C:17]([N:19]4[CH2:23][CH2:22][CH2:21][CH2:20]4)[NH:16][N:15]=3)[N:11]=2)[C:7]=1[CH3:8]

Participants

3

Reactant 1

HCID 72705474HCID 72705474, compound

Product 1

HCID 178427934HCID 178427934, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

6,8-Dichloro-2-(2-(1-(4-methoxybenzyl)-5-(pyrrolidin-1-yl)-1H-1,2,4-triazol-3-yl)ethyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyridine (17 mg, 35.0 μmol, Eq: 1.00) in trifluoroacetic acid (539 μl) was heated 3 h under reflux. The product (12.8 mg, 100%) was obtained as a white solid by preparative HPLC. MS: m/z=366.2 (M+H+)

Workup

  1. temperatureunder reflux

Sources & evidence

ORD record
ord-f7c5a5f830d444e5b5ed5d99e9f36f4e
Source dataset
uspto-grants-2016_07
Patent number
US09394311B2

Reaction notes

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