HCID 90017318, compound → HCID 90018297, compound

HRID 1054998Notes

Reaction equation

HRID 1054998 reaction equation
COC1C=CC(C[NH:8][C:9]2[C:14]([C:15]([F:18])([F:17])[F:16])=[CH:13][CH:12]=[C:11]([CH3:19])[N:10]=2)=CC=1>FC(F)(F)C(O)=O>[CH3:19][C:11]1[N:10]=[C:9]([NH2:8])[C:14]([C:15]([F:18])([F:16])[F:17])=[CH:13][CH:12]=1

Participants

3

Reactant 1

HCID 90017318HCID 90017318, compound

Product 1

HCID 90018297HCID 90018297, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

N-(4-Methoxybenzyl)-6-methyl-3-(trifluoromethyl)pyridin-2-amine (100 mg, 338 μmol, Eq: 1.00) in trifluoroacetic acid (2 ml) was heated under reflux for 30 min. The mixture was concentrated. The crude product (120 mg, pink solid) was used in the next step without further purification. MS: m/z=218.2 (M+H+)

Workup

  1. temperatureunder reflux for 30 min
  2. concentrationThe mixture was concentrated
  3. customThe crude product (120 mg, pink solid) was used in the next step without further purification

Sources & evidence

ORD record
ord-f692e6c33e7346948fe289090a178efd
Source dataset
uspto-grants-2016_07
Patent number
US09394311B2

Reaction notes

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