Hydrochloric Acid → HCID 72705844, compound

HRID 1055005Notes

Reaction equation

HRID 1055005 reaction equation
Cl.[CH2:2]([C:4]1[C:5]2[N:6]([C:11]([CH2:14][CH2:15][C:16]3[N:20]([CH3:21])[N:19]=[C:18]([N:22]4[CH2:26][CH2:25][CH2:24][CH2:23]4)[N:17]=3)=[N:12][N:13]=2)[C:7]([CH3:10])=[N:8][CH:9]=1)[CH3:3]>CO>[CH2:2]([C:4]1[C:5]2[N:13]([N:12]=[C:11]([CH2:14][CH2:15][C:16]3[N:20]([CH3:21])[N:19]=[C:18]([N:22]4[CH2:26][CH2:25][CH2:24][CH2:23]4)[N:17]=3)[N:6]=2)[C:7]([CH3:10])=[N:8][CH:9]=1)[CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric Acid2×HCID 90017711HCID 90017711, compound

Product 1

HCID 72705844HCID 72705844, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent3×

Procedure

1.25 N HCl in methanol (57.3 μl, 71.7 μmol) was added to a solution of 8-ethyl-5-methyl-3-(2-(1-methyl-3-(pyrrolidin-1-yl)-1H-1,2,4-triazol-5-yl)ethyl)-[1,2,4]triazolo[4,3-c]pyrimidine (24.4 mg, 71.7 μmol) in methanol (2 mL). The reaction mixture was stirred at room temperature for 2 h. Additional 1.25 N HCl in methanol (57.3 μl, 71.7 μmol) was added and the mixture was stirred for 15 min. The solvent was evaporated. The crude product was purified with preparative HPLC to afford the desired product (20 mg, 82%) as a white solid. MS: m/z=341.2 (M+H+)

Workup

  1. stirringthe mixture was stirred for 15 min
  2. customThe solvent was evaporated
  3. customThe crude product was purified with preparative HPLC

Sources & evidence

ORD record
ord-0bc18b8f56664babade277e675a20b12
Source dataset
uspto-grants-2016_07
Patent number
US09394311B2

Reaction notes

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