反应详情

Add hydrogen chloride (1N, 0.62 mL; 1.05 equiv; 0.62 mmoles) to a solution of 5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-6-ylmethyl 2-(2,3-dihydro-1H-inden-2-ylamino)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxylate isomer 2 (0.254 g; 1.00 equiv; 0.59 mmoles) in isopropyl alcohol (0.3 mL). Swirl the mixture until dissolution occurs, freeze the solution in a −78° C. dry ice bath, and lyophilize to afford 5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-6-ylmethyl 2-(2,3-dihydro-1H-inden-2-ylamino)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxylate hydrochloride isomer 2 (0.28 g; 100%) as a brown foam. MS (m/z): 431(M+1).

1. dissolutionSwirl the mixture until dissolution
2. customin a −78° C.