3-Amino-1-propanol → HCID 5215034, compound
Reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][OH:5].[CH2:6]=[C:7]1[O:11][C:9](=[O:10])[CH2:8]1>O1CCCC1>[OH:5][CH2:4][CH2:3][CH2:2][NH:1][C:9](=[O:10])[CH2:8][C:7](=[O:11])[CH3:6]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
28 ml (0.38 mmol) of 3-amino-1-propanol were added dropwise to a solution of 30 g of diketene (0.36 mol) in 300 ml tetrahydrofuran at −5 to 0° C. After 1 h stirring at 0° C. no more starting material was detected by thin layer chromatography. The reaction mixture was evaporated and the residue purified by column chromatography. This gave 47.15 g (0.30 mol, 83% yield) of a white solid.
Workup
- customThe reaction mixture was evaporated
- customthe residue purified by column chromatography
Sources & evidence
- ORD record
- ord-ab00203f0acf46cc90fa17eaccc7b57d
- Source dataset
- uspto-grants-2016_07
- Patent number
- US09394324B2
Reaction notes
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