1-Amino-2-propanol → HCID 61251402, compound

HRID 1055217Notes

Reaction equation

HRID 1055217 reaction equation
[NH2:1][CH2:2][CH:3]([OH:5])[CH3:4].[CH2:6]=[C:7]1[O:11][C:9](=[O:10])[CH2:8]1>O1CCCC1>[OH:5][CH:3]([CH3:4])[CH2:2][NH:1][C:9](=[O:10])[CH2:8][C:7](=[O:11])[CH3:6]

Participants

4

Reactant 2

HCID 41-Amino-2-propanolHCID 12661Diketene

Product 1

HCID 61251402HCID 61251402, compoundYield 79.2%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
0 °C

Procedure

19 ml (0.24 mol) 1-amino-2-propanol were added dropwise to a solution of 20 g of diketene (0.24 mol) in 200 ml tetrahydrofuran at −5 to 0° C. After 1 h stirring at 0° C. no more starting material was detected by thin layer chromatography. The reaction mixture was evaporated and the residue purified by column chromatography. This gave 29.50 g (0.19 mol, 78% yield) of a colorless oil.

Workup

  1. customThe reaction mixture was evaporated
  2. customthe residue purified by column chromatography

Sources & evidence

ORD record
ord-64d3ebbf4d234088ba2d40019e25a1b9
Source dataset
uspto-grants-2016_07
Patent number
US09394324B2

Reaction notes

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