Trifluoroacetic acid → HCID 86711157, compound

HRID 1055266Notes

Reaction equation

HRID 1055266 reaction equation
[F:1][C:2]1[CH:41]=[CH:40][C:5]2[C:6]([CH:9]3[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][C:17]4[C:22](=[O:23])[N:21]5[CH2:24][CH2:25][CH2:26][CH:27]([O:28][CH2:29][CH2:30][CH2:31][NH:32]C(=O)C(C)(C)C)[C:20]5=[N:19][C:18]=4[CH3:39])[CH2:11][CH2:10]3)=[N:7][O:8][C:4]=2[CH:3]=1.FC(F)(F)C(O)=O>ClCCl>[NH2:32][CH2:31][CH2:30][CH2:29][O:28][CH:27]1[C:20]2=[N:19][C:18]([CH3:39])=[C:17]([CH2:16][CH2:15][N:12]3[CH2:11][CH2:10][CH:9]([C:6]4[C:5]5[CH:40]=[CH:41][C:2]([F:1])=[CH:3][C:4]=5[O:8][N:7]=4)[CH2:14][CH2:13]3)[C:22](=[O:23])[N:21]2[CH2:24][CH2:25][CH2:26]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86711158HCID 86711158, compound

Product 1

HCID 86711157HCID 86711157, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of N-(3-((3-(2-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-2-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-9-yl)oxy)propyl)pivalamide, prepared as described in Step A, (1.482 g, 2.54 mmol) in dichloromethane (10 mL) and trifluoroacetic acid (5 mL) was stirred for 1 h at room temperature. The reaction mixture was purified on a Porapak CX column to give the title compound which was used without further purification in the next step.

Workup

  1. customThe reaction mixture was purified on a Porapak CX column

Sources & evidence

ORD record
ord-987a0d2c9d5748b3b24f173af09ae126
Source dataset
uspto-grants-2016_07
Patent number
US09394354B2

Reaction notes

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