反应详情

Geraniol (3 g, 0.0194 mol) and olivetol (2 g, 0.0111 mol) were dissolved in 400 mL of chloroform containing 80 mg of p-toluenesulfonic acid as catalyst and the reaction mixture was stirred at room temperature for 12 h in the dark. After 12 hours, the reaction mixture was washed with saturated sodium bicarbonate (400 mL) and then with H2O (400 mL). The chloroform layer was concentrated at 40 C under reduced pressure, and the residue obtained was chromatographed on a 2.0 cm×25 cm silica gel column using benzene (1000 mL) as the eluent to give 1.4 g (0.00442 mol)(39.9%) CBG as product.

1. waitAfter 12 hours
2. washthe reaction mixture was washed with saturated sodium bicarbonate (400 mL)
3. concentrationThe chloroform layer was concentrated at 40 C under reduced pressure
4. customthe residue obtained
5. customwas chromatographed on a 2.0 cm×25 cm silica gel column
6. customto give 1.4 g (0.00442 mol)(39.9%) CBG as product