Cesium carbonate → HCID 89699819, compound

HRID 1055637Notes

Reaction equation

[CH3:1][O:2][CH:3]([O:26][CH3:27])[CH:4]([N:6]1[C:10]([NH2:11])=[CH:9][C:8]([C:12]2[CH:13]=[N:14][N:15]([CH2:17][C:18]3[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=3)[CH:16]=2)=[N:7]1)[CH3:5].Br[C:29]1[CH:34]=[C:33]([N+:35]([O-:37])=[O:36])[CH:32]=[CH:31][C:30]=1[CH3:38].CC1(C)C2C(=C(P(C3C=CC=CC=3)C3C=CC=CC=3)C=CC=2)OC2C(P(C3C=CC=CC=3)C3C=CC=CC=3)=CC=CC1=2.C(=O)([O-])[O-].[Cs+].[Cs+]>O1CCOCC1.C([O-])(=O)C.[Pd+2].C([O-])(=O)C>[CH3:27][O:26][CH:3]([O:2][CH3:1])[CH:4]([N:6]1[C:10]([NH:11][C:29]2[CH:34]=[C:33]([N+:35]([O-:37])=[O:36])[CH:32]=[CH:31][C:30]=2[CH3:38])=[CH:9][C:8]([C:12]2[CH:13]=[N:14][N:15]([CH2:17][C:18]3[CH:19]=[CH:20][C:21]([O:24][CH3:25])=[CH:22][CH:23]=3)[CH:16]=2)=[N:7]1)[CH3:5]

Participants

Conditions

Temperature: 150 °C

Procedure

980 mg (2.64 mmol) of the compound of Example 3A and 627 mg (2.90 mmol) of 2-bromo-4-nitrotoluene were dissolved in 13 ml of dioxane, the mixture was degassed with argon and 59 mg (0.26 mmol) of palladium(II) acetate, 229 mg (0.40 mmol) of xantphos [4,5-bis(diphenylphosphino)-9,9-dimethylxanthene] and 2.57 g (7.91 mmol) of caesium carbonate were added. The mixture was heated in a microwave oven (Biotage Initiator, with Dynamic Field Tuning) at 150° C. for 30 min. The reaction was then filtered through kieselguhr, the filtrate was concentrated under reduced pressure and the residue was subjected to flash chromatography on silica gel (mobile phase dichloromethane/ethyl acetate 2:1). This gave 980 mg (73% of theory) of the title compound.

Workup

additionwere added
filtrationThe reaction was then filtered through kieselguhr
concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record: ord-7ebd227208dc4c63a8b1dddc4f1147b6
Source dataset: uspto-grants-2016_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09394309B2

Reaction notes

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