反应详情

A mixture of 2-phenoxyquinoline-8-carboxylic acid (178c 217 mg, 0.818 mmol), 3-aminopyridine-2,4-diol (155 mg, 1.227 mmol), HATU (622 mg, 1.636 mmol), and DIPEA (438 μl, 2.454 mmol) in DMF (1636 μl) was stirred at RT for 1 h. Purification by silica gel (100% DCM to 5% MeOH/DCM) provided N-(2,4-dihydroxypyridin-3-yl)-2-phenoxyquinoline-8-carboxamide (179c) as a yellow solid. MS (ESI, pos. ion) m/z: 374.2 (M+1).

1. customPurification by silica gel (100% DCM to 5% MeOH/DCM)