反应详情

温度

150 °C

To 96.3 g (1660 mmol) of spray-dried potassium fluoride, was added a solution of 129.2 g (664 mmol) of 5-chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde in 1000 ml of dimethylformamide. The resulting reaction mixture was stirred at 150° C. for 3 hours. The reaction mixture was cooled to room temperature and to it was added 4 L of water. The aqueous phase was extracted with ethyl acetate. The combined organic phase were washed with brine, dried over sodium sulphate and evaporated under vacuum to give the expected product.

1. customThe resulting reaction mixture
2. temperatureThe reaction mixture was cooled to room temperature and to it
3. extractionThe aqueous phase was extracted with ethyl acetate
4. washThe combined organic phase were washed with brine
5. dry with materialdried over sodium sulphate
6. customevaporated under vacuum