反应详情

The title compound was prepared according to the procedure as described in Example 10 Step 2 using a solution of N-(3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide (0.2 g, 0.4 mmol) in DMF (1 mL), KOH (46 mg, 0.80 mmol), a solution of TBAB (264 mg, 0.81 mmol) in DMF (0.5 mL) and a solution of 1-chloro-2-methylpropyl propionate (81 mg, 0.49 mmol) in DMF (0.5 mL). The title compound was obtained as a white solid (114 mg, 45%). The title compound was characterized by LC-MS and 1H NMR as shown below:

1. customThe title compound was prepared