Triethylsilane → HCID 118566580, compound

HRID 1056780Notes

Reaction equation

HRID 1056780 reaction equation
[F:1][C:2]1([F:29])[CH2:7][CH2:6][CH:5]([CH2:8][NH:9][C:10]([C:12]2[C:13]3[CH:14]=[CH:15][C:16]([C:23]4[CH2:28][CH2:27][CH2:26][CH2:25][CH:24]=4)=[N:17][C:18]=3[CH:19]=[CH:20][C:21]=2[Cl:22])=[O:11])[CH2:4][CH2:3]1.C([SiH](CC)CC)C>[Pd]>[F:29][C:2]1([F:1])[CH2:3][CH2:4][CH:5]([CH2:8][NH:9][C:10]([C:12]2[C:13]3[CH:14]=[CH:15][C:16]([CH:23]4[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28]4)=[N:17][C:18]=3[CH:19]=[CH:20][C:21]=2[Cl:22])=[O:11])[CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 12052TriethylsilaneHCID 118566602HCID 118566602, compound

Product 1

HCID 118566580HCID 118566580, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

The title compound was synthesized according to the procedure described in example 126 using 6-chloro-2-cyclohex-1-enyl-quinoline-5-carboxylic acid (4,4-difluoro-cyclohexyl methyl)-amide, palladium on carbon and triethylsilane. 1H NMR (400 MHz, DMSO-d6): δ ppm 8.78-8.80 (m, 1H), 7.96-7.95 (m, 1H), 7.76 (d, J=9.04 Hz, 1H), 7.59 (d, J=8.80 Hz, 1H), 3.25-3.40 (m, 2H), 2.85-2.95 (m, 1H), 2.01-2.15 (m, 2H), 1.86-1.99 (m, 10H), 1.55-1.60 (m, 2H), 1.40-1.45 (m, 2H), 1.23-1.26 (m, 3H). m/z: 421 [M+H]+

Sources & evidence

ORD record
ord-b7c88d6f66c549bcb1598b2d373d4c55
Source dataset
uspto-grants-2016_07
Patent number
US09399623B2

Reaction notes

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