4-Chlorophenol → 4-[2-(4-Chlorophenoxy)-4-(methylamino)-3-nitrophenyl]-6-methyl-1-{[2-(trimethylsilyl)ethoxy]methyl}-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one

HRID 1056998Notes

Reaction equation

HRID 1056998 reaction equation
F[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[C:6]([NH:11][CH3:12])[CH:5]=[CH:4][C:3]=1[C:13]1[C:14]2[CH:23]=[CH:22][N:21]([CH2:24][O:25][CH2:26][CH2:27][Si:28]([CH3:31])([CH3:30])[CH3:29])[C:15]=2[C:16](=[O:20])[N:17]([CH3:19])[CH:18]=1.[Cl:32][C:33]1[CH:38]=[CH:37][C:36]([OH:39])=[CH:35][CH:34]=1>>[Cl:32][C:33]1[CH:38]=[CH:37][C:36]([O:39][C:2]2[C:7]([N+:8]([O-:10])=[O:9])=[C:6]([NH:11][CH3:12])[CH:5]=[CH:4][C:3]=2[C:13]2[C:14]3[CH:23]=[CH:22][N:21]([CH2:24][O:25][CH2:26][CH2:27][Si:28]([CH3:31])([CH3:30])[CH3:29])[C:15]=3[C:16](=[O:20])[N:17]([CH3:19])[CH:18]=2)=[CH:35][CH:34]=1

Participants

3

Reactant 2

HCID 46844-ChlorophenolHCID 1235864014-[2-Fluoro-4-(methylamino)-3-nitrophenyl]-6-methyl-1-{[2-(trimethylsilyl)ethoxy]methyl}-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one

Product 1

HCID 1239108154-[2-(4-Chlorophenoxy)-4-(methylamino)-3-nitrophenyl]-6-methyl-1-{[2-(trimethylsilyl)ethoxy]methyl}-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one

Procedure

This compound was synthesized according to the procedure of Example 1, Step 1, using 4-[2-fluoro-4-(methylamino)-3-nitrophenyl]-6-methyl-1-{[2-(trimethylsilyl)ethoxy]methyl}-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one and p-chlorophenol as the starting materials. LCMS calculated for C27H32ClN4O5Si (M+H)+: m/z=555.2. found: 555.1.

Workup

  1. customThis compound was synthesized

Sources & evidence

ORD record
ord-02eefd63dd084aea99264eccab6c0f96
Source dataset
uspto-grants-2016_07
Patent number
US09399640B2

Reaction notes

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