反应详情

16 g (60%) of sodium hydride was dispersed in 20 ml of tetrahydrofuran. To this, 100 ml of a solution in which 50 g of p-nitrobenzyl alcohol was dissolved in tetrahydrofuran, was added in drops while cooling with ice. The mixture was stirred for one hour at room temperature, and thereafter 56 g of iodomethane was added in drops while cooling with ice, and the mixture was further stirred for 3 hours at room temperature. To the reaction solution was added water, and a mixture was extracted with ethyl acetate. The extracted solvent was distilled off under reduced pressure, and the resulting product was purified by silica gel chromatography to obtain 40 g of p-methoxymethylnitrobenzene.

1. additionwas added in drops
2. temperaturewhile cooling with ice
3. temperaturewhile cooling with ice
4. stirringthe mixture was further stirred for 3 hours at room temperature
5. extractiona mixture was extracted with ethyl acetate
6. distillationThe extracted solvent was distilled off under reduced pressure
7. customthe resulting product was purified by silica gel chromatography