反应详情

5-Chloroethyl-2-oxindole (2.3 g), 1.2 mL of morpholine and 1.2 mL of diisopropylethylamine were heated overnight at 100° C. in 10 mL of dimethylsulfoxide. The mixture ws cooled, poured into water and extacted with ethyl acetate. The organic layer was washed with brine, dried and evaporated. The residue was chromatographed on silica gel in 5% methanol in chloroform to give 0.9 g (31%) of the title compound as a white solid.

1. temperatureThe mixture ws cooled
2. washThe organic layer was washed with brine
3. customdried
4. customevaporated
5. customThe residue was chromatographed on silica gel in 5% methanol in chloroform