3-Amino-1-propanol → HCID 18671394, compound

HRID 1057472Notes

Reaction equation

HRID 1057472 reaction equation
CCN(C(C)C)C(C)C.[NH2:10][CH2:11][CH2:12][CH2:13][OH:14].[Br:15][C:16]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][C:17]=1[CH2:18]Br>C(#N)C>[Br:15][C:16]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][C:17]=1[CH2:18][NH:10][CH2:11][CH2:12][CH2:13][OH:14]

Participants

5

Reactant 3

HCID 90863-Amino-1-propanolHCID 81531DiisopropylethylamineHCID 5179721-Bromo-2-(bromomethyl)-4-fluorobenzene

Product 1

HCID 18671394HCID 18671394, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Hunig's base (1.3 eq) and 3-aminopropan-1-ol (1.3 eq) were added to a solution of 2-bromo-5-fluoro-benzyl bromide (1 eq) in acetonitrile (0.6 M) and the resulting mixture stirred at RT under nitrogen for 12 h. Concentrated in vacuo to give 3-(((2-bromo-5-fluorophenyl)methyl)amino)propan-1-ol as a clear oil. EI-MS m/z 262, 264 (M+H)+

Workup

  1. concentrationConcentrated in vacuo

Sources & evidence

ORD record
ord-32e818d9d1174a19bc8de7f363f7655c
Source dataset
uspto-grants-2003_02
Patent number
US06514964B1

Reaction notes

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