反应详情

N-(2-(2-Bromophenyl)ethyl)-N-(phenylmethyl)amine was dissolved in acetonitrile (0.2 M), followed by addition of methyl 4-bromocrotonate (1.2 eq) and triethylamine (1.5 eq), and the reaction was refluxed overnight. After cooling to room temperature, the reaction was diluted with EtOAc, washed with 10% sodium carbonate, water, and brine, dried over magnesium sulfate, filtered and concentrated in vacuo. Flash chromatography (silica; 50% EtOAc/Hex) afforded a colorless oil. EI-MS m/z 388/390 (M+H)+

1. temperaturethe reaction was refluxed overnight
2. washwashed with 10% sodium carbonate, water, and brine
3. dry with materialdried over magnesium sulfate
4. filtrationfiltered
5. concentrationconcentrated in vacuo
6. customFlash chromatography (silica; 50% EtOAc/Hex) afforded a colorless oil