4-(4-Fluorophenoxy)-2-(prop-2-en-1-yl)phenol → 4-(4-Fluorophenoxy)-2-propylphenol

HRID 1057815Notes

Reaction equation

HRID 1057815 reaction equation
[F:1][C:2]1[CH:18]=[CH:17][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([OH:13])=[C:9]([CH2:14][CH:15]=[CH2:16])[CH:8]=2)=[CH:4][CH:3]=1>C(OCC)(=O)C.[Pd]>[F:1][C:2]1[CH:18]=[CH:17][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([OH:13])=[C:9]([CH2:14][CH2:15][CH3:16])[CH:8]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 186724734-(4-Fluorophenoxy)-2-(prop-2-en-1-yl)phenol

Product 1

HCID 187722564-(4-Fluorophenoxy)-2-propylphenol

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A solution of 4-(4-fluorophenoxy)-2-allylphenol (2.30 g, 9.42 mmol) and 5% Pd/C (0.90 g) in ethyl acetate (30 mL) was stirred under H2 atmosphere for 3 h at room temperature. The reaction mixture was filtered through a short pad of silica gel and concentrated in vacuo to afford the title compound which was used as is.

Workup

  1. filtrationThe reaction mixture was filtered through a short pad of silica gel
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-70b5fe82cc19412f8a4f5ec0e7788ea6
Source dataset
uspto-grants-2003_02
Patent number
US06515015B1

Reaction notes

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