Cyclobutylamine → HCID 22734150, compound

HRID 1057912Notes

Reaction equation

HRID 1057912 reaction equation
[CH3:1][O:2][C:3]1[C:11]2[O:10][C:9]([C:12]([OH:14])=O)=[CH:8][C:7]=2[CH:6]=[CH:5][CH:4]=1.[CH:15]1([NH2:19])[CH2:18][CH2:17][CH2:16]1>>[CH:15]1([NH:19][C:12]([C:9]2[O:10][C:11]3[C:3]([O:2][CH3:1])=[CH:4][CH:5]=[CH:6][C:7]=3[CH:8]=2)=[O:14])[CH2:18][CH2:17][CH2:16]1

Participants

3

Reactant 2

HCID 75645CyclobutylamineHCID 6060377-Methoxy-1-benzofuran-2-carboxylic acid

Product 1

HCID 22734150HCID 22734150, compound

Procedure

Substantially the same procedure as in Example 219 was repeated using a starting material, 7-methoxybenzofuran-2-carboxylic acid, and cyclobutylamine to give N-Cyclobutyl-7-methoxybenzofuran-2-carboxamide (Compound 289a). Successively, it was formylated to give N-cyclobutyl-4-formyl-7-methoxybenzofuran-2-carboxamide (Compound 289b), then compound 289b was reacted with methylamine hydrochloride to give Compound 289 as a white solid.

Sources & evidence

ORD record
ord-2e5a0367c4c749c4946133972af8f12b
Source dataset
uspto-grants-2003_02
Patent number
US06514996B2

Reaction notes

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