Triphenylphosphine Oxide → HCID 22661302, compound

HRID 1058389Notes

Reaction equation

HRID 1058389 reaction equation
C[O:2][C:3](=[O:22])[C:4]1[CH:9]=[CH:8][C:7]([C:10]([NH:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([OH:20])[CH:15]=2)=[O:11])=[CH:6][C:5]=1[CH3:21].C1(P(=O)(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.O.[OH-].[Li+]>O1CCCC1.CO.O>[OH:20][C:16]1[CH:15]=[C:14]([CH:19]=[CH:18][CH:17]=1)[CH2:13][NH:12][C:10]([C:7]1[CH:8]=[CH:9][C:4]([C:3]([OH:22])=[O:2])=[C:5]([CH3:21])[CH:6]=1)=[O:11]

Participants

6

Reactant 3

HCID 13097Triphenylphosphine OxideHCID 168937Lithium hydroxide, monohydrateHCID 70029470HCID 70029470, compound

Product 1

HCID 22661302HCID 22661302, compoundYield 34%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 21899815MeOH tetrahydrofuranSolvent

Procedure

A solution of 4-(methoxycarbonyl)-3-methylbenzoic acid (Example 89; 4.83 g, 24.9 mmol) and triphenylphosphine (7.37 g, 28.1 mmol) in dichloromethane (100 mL) was cooled to ˜0° C. and N-chlorosuccinimide (3.75 g, 28.1 mmol) was added portionwise. The solution was allowed to warm to room temperature and stirred for 30 min. 3-Hydroxybenzylamine (Example 69; 4.00 g, 33.0 mmol) and diisopropylethylamine (4.00 g, 30.9 mmol) were added and the solution was allowed to stir at room temperature for 72 h. The solution was washed with 1N hydrochloric acid solution, water and brine (200 mL each), dried (MgSO4), filtered and evaporated to give a colorless solid (13.34 g) which contained 4-[[(3-hydroxybenzyl)amino]carbonyl]-2-methylbenzoic acid methyl ester and triphenylphosphine oxide. The solid was taken up in tetrahydrofuran/methanol (3:1; 200 mL) and a solution of lithium hydroxide monohydrate (4.00 g, 95.3 mmol) in water (50 mL) was added. The solution was stirred at room temperature for 4 h and then the solvent was evaporated under reduced pressure. The residual material was taken up in a mixture of 1N sodium hydroxide and diethyl ether (200 mL each) and the mixture was filtered to remove undissolved solids. The diethyl ether layer was discarded and the aqueous basic layer of the filtrate was acidified with conc. hydrochloric acid solution to ˜pH 1. The mixture was extracted with ethyl acetate (2×100 mL) and the combined organic layers were washed with brine (200 mL), dried (MgSO4), filtered and evaporated to give 4-[[(3-hydroxybenzyl)amino]carbonyl]-2-methylbenzoic acid as a colorless solid (2.40 g, 34% yield).

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. additionThe residual material was taken up in a mixture of 1N sodium hydroxide and diethyl ether (200 mL each)
  3. filtrationthe mixture was filtered
  4. customto remove undissolved solids
  5. extractionThe mixture was extracted with ethyl acetate (2×100 mL)
  6. washthe combined organic layers were washed with brine (200 mL)
  7. dry with materialdried (MgSO4)
  8. filtrationfiltered
  9. customevaporated

Sources & evidence

ORD record
ord-fc76fd3062a749129e23a63716e2265f
Source dataset
uspto-grants-2003_02
Patent number
US06515124B2

Reaction notes

Loading…