Chloride → 2,2-Dimethyl-propionic acid 5-bromo-3-(3-chloro-benzyl)-pyrazolo[3,4-b]pyridin-1-ylmethyl ester

HRID 105851Notes

Reaction equation

HRID 105851 reaction equation
[Br:1][c:2]1[cH:3][c:4]2[c:5]([n:6][cH:7]1)[n:8]([CH2:12][O:13][C:14]([C:15]([CH3:16])([CH3:17])[CH3:18])=[O:19])[n:9][c:10]2[I:11].[Cl-:20].[Cl:21][c:22]1[cH:23][c:24]([CH2:25][Zn+:26])[cH:27][cH:28][cH:29]1.[O:30]1[CH2:31][CH2:32][CH2:33][CH2:34]1>>[Br:1][c:2]1[cH:3][c:4]2[c:5]([n:6][cH:7]1)[n:8]([CH2:12][O:13][C:14]([C:15]([CH3:16])([CH3:17])[CH3:18])=[O:19])[n:9][c:10]2[CH2:25][c:24]1[cH:23][c:22]([Cl:21])[cH:29][cH:28][cH:27]1

Participants

5

Reactant 4

HCID 312ChlorideHCID 8028TetrahydrofuranHCID 579757462,2-Dimethyl-propionic acid 5-bromo-3-iodo-pyrazolo[3,4-b]pyridin-1-ylmethyl esterHCID 178478086HCID 178478086, compound

Product 1

HCID 686623032,2-Dimethyl-propionic acid 5-bromo-3-(3-chloro-benzyl)-pyrazolo[3,4-b]pyridin-1-ylmethyl ester

Sources & evidence

ORD record
ord-a5e21085fd564015ac5a18ba7393f01f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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