Benzoic Acid → Methoxyacetic Acid

HRID 105862Notes

Reaction equation

HRID 105862 reaction equation
[Cl:1][c:2]1[cH:3][c:4]([NH:17][c:18]2[n:19][cH:20][n:21][c:22]3[cH:23][cH:24][c:25]([NH:28][C:29]([CH2:30][CH2:31][NH:32][C:33]([CH2:34][O:35][CH3:36])=[O:37])=[O:38])[cH:26][c:27]23)[cH:5][cH:6][c:7]1[O:8][CH2:9][c:10]1[cH:11][c:12]([F:16])[cH:13][cH:14][cH:15]1.[OH:39][C:40]([c:41]1[cH:42][cH:43][cH:44][cH:45][cH:46]1)=[O:47]>>[C:33]([CH2:34][O:35][CH3:36])([OH:37])=[O:39].[Cl:1][c:2]1[cH:3][c:4]([NH:17][c:18]2[n:19][cH:20][n:21][c:22]3[cH:23][cH:24][c:25]([NH:28][C:29]([CH2:30][CH2:31][NH2:32])=[O:38])[cH:26][c:27]23)[cH:5][cH:6][c:7]1[O:8][CH2:9][c:10]1[cH:11][c:12]([F:16])[cH:13][cH:14][cH:15]1

Participants

4

Reactant 2

HCID 243Benzoic AcidHCID 11562882N-{4-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]-quinazolin-6-yl}-3-(2-methoxy-acetylamino)-propionamide

Product 2

HCID 12251Methoxyacetic AcidHCID 673341233-Amino-N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl)propanamide

Sources & evidence

ORD record
ord-3711637c6add4c22b40e19764779359b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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