Dimethylformamide → HCID 18668784, compound

HRID 1058637Notes

Reaction equation

HRID 1058637 reaction equation
[Cl:1][C:2]1[C:11]2[N:12]=[C:13]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[N:14]([CH2:15][CH2:16][CH:17]3[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]3)[C:10]=2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[N:3]=1.C([N:31]([CH2:34]C)CC)C.C[N:37](C)C=O>>[ClH:1].[C:34]([N:20]1[CH2:21][CH2:22][CH:17]([CH2:16][CH2:15][N:14]2[C:10]3[C:9]4[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=4[N:3]=[C:2]([Cl:1])[C:11]=3[N:12]=[C:13]2[C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH2:18][CH2:19]1)(=[NH:31])[NH2:37]

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 9930351HCID 9930351, compound

Product 1

HCID 18668784HCID 18668784, compound

Procedure

A solution of 0.75 g of 4-chloro-2-phenyl-1-[2-(4-piperidyl)ethyl]-1H-imidazo-[4,5-c]quinoline, 0.40 g of 1H-pyrazole-1-carboxyamidine hydrochloride and 0.39 ml of triethylamine in 5 ml of N,N-dimethylformamide was stirred at room temperature for 19 hours. The reaction solution was concentrated and the residue was added with ethanol, and then the precipitated crystals were collected by filtration to give 0.51 g of colorless crystals. Recrystallization from ethanol gave colorless crystals having the melting point of from 270 to 273° C. (decomposition).

Workup

  1. concentrationThe reaction solution was concentrated
  2. additionthe residue was added with ethanol
  3. filtrationthe precipitated crystals were collected by filtration

Sources & evidence

ORD record
ord-4e2fb6475b7c4f0199188d0defb1e6cd
Source dataset
uspto-grants-2003_02
Patent number
US06518265B1

Reaction notes

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