Triethylamine → HCID 18668970, compound

HRID 1058662Notes

Reaction equation

F[C:2]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][C:3]=1[CH:4]=[O:5].[SH:13][C:14]1[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=1.C(N(CC)CC)C>CN(C)C=O>[N+:10]([C:7]1[CH:8]=[CH:9][C:2]([S:13][C:14]2[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=2)=[C:3]([CH:6]=1)[CH:4]=[O:5])([O-:12])=[O:11]

Participants

Conditions

Temperature: 25 °C

Procedure

2-Fluoro-5-nitrobenzaldehyde (0.16 g, 0.95 mmol) was dissolved in N,N-dimethylformamide (8.1 mL), and 4-mercaptophenol (0.11 g, 0.86 mmol) and triethylamine (0.27 mL, 1.9 mmol) were added thereto, followed by stirring at 25° C. for 1 hour. After the conventional treatment, the product was purified by silica gel column chromatography (eluted by n-hexane/acetone=4/1-1/1) to give 5-nitro-2-[(4-hydroxyphenyl)thio]benzaldehyde (0.18 g, 70%).

Workup

customAfter the conventional treatment, the product was purified by silica gel column chromatography (eluted by n-hexane/acetone=4/1-1/1)

Sources & evidence

ORD record: ord-29202115b2a54a23b6bde3ef2473f114
Source dataset: uspto-grants-2003_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06518268B1

Reaction notes

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