HCID 18669451, compound → HCID 18669456, compound

HRID 1058934Notes

Reaction equation

HRID 1058934 reaction equation
[CH:1]([NH:4][C:5](=[O:12])[N:6]([CH2:8][C:9](O)=[O:10])[CH3:7])([CH3:3])[CH3:2]>O.Cl>[CH:1]([N:4]1[C:9](=[O:10])[CH2:8][N:6]([CH3:7])[C:5]1=[O:12])([CH3:3])[CH3:2]

Participants

4

Reactant 1

HCID 18669451HCID 18669451, compound

Product 1

HCID 18669456HCID 18669456, compoundYield 100.3%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 962WaterSolvent2×

Procedure

A mixture of 14.9 g of (3-isopropyl-1-methylureido)acetic acid in 50 ml of water and 50 ml of concentrated hydrochloric acid was refluxed for 2 h. On cooling the mixture was diluted with water and extracted with ethyl acetate to give 13.4 g of a colourless oil. Mass spectrum (EI) m/z 156 M+.

Workup

  1. temperaturewas refluxed for 2 h
  2. temperatureOn cooling the mixture
  3. extractionextracted with ethyl acetate

Sources & evidence

ORD record
ord-cca452dc76f3472080a859b30d98b049
Source dataset
uspto-grants-2003_02
Patent number
US06518293B2

Reaction notes

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