Benzyl Bromide → N-benzyloxy-tert-butyl-(dimethyl-tert-butylaminocarbonyl-methyl)-amine

HRID 1059039Notes

Reaction equation

HRID 1059039 reaction equation
[CH2:1]([O:4][N:5]([C:16]([CH3:19])([CH3:18])[CH3:17])[C:6]([CH3:15])([CH3:14])[C:7]([NH:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[CH:2]=[CH2:3].C(N(C(C)(C)C(NC(C)(C)C)=O)O)(C)(C)C.[CH2:36](Br)[C:37]1C=CC=[CH:39][CH:38]=1>>[CH2:1]([O:4][N:5]([C:16]([CH3:19])([CH3:18])[CH3:17])[C:6]([CH3:15])([CH3:14])[C:7]([NH:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[C:2]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:3]=1

Participants

4

Reactant 3

HCID 7498Benzyl BromideHCID 11207972N-allyloxy-tert-butyl-(dimethyl-tert-butylaminocarbonyl-methyl)-amineHCID 22182216Tert-butyl-(dimethyl-tert-butylaminocarbonyl-methyl)-hydroxylamine

Product 1

HCID 22598530N-benzyloxy-tert-butyl-(dimethyl-tert-butylaminocarbonyl-methyl)-amineYield 92%

Procedure

The compound is prepared in analogy to compound (204) from tert-butyl-(dimethyl-tert-butylaminocarbonyl-methyl)-hydroxylamine and benzylbromide in 92% yield as colorless oil. Elemental analysis calculated for C19H32N2O2: C 71.21%; H 10.06%; N 8.74%. Found: C 71.22%; H 10.07%; N 8.94%.

Sources & evidence

ORD record
ord-1961c034242847b5ab512583739454df
Source dataset
uspto-grants-2003_02
Patent number
US06518326B1

Reaction notes

Loading…