反应详情

A 2 l three-necked flask, is charged with 121.8 g of 2,6-dimethylaniline, 300 ml of isopropyl ether and 150 ml of water. 126.5 g of 3-chloropropanoyl chloride are added at a rate such that the internal temperature is between 5 and 10° C. At the end of the addition, the reaction medium is stirred for 3 h. The precipitate formed is filtered off with suction, washed with isopropyl ether and then with water and finally dried. 126 g of white crystals are obtained.

1. customis between 5 and 10° C
2. additionAt the end of the addition
3. customThe precipitate formed
4. filtrationis filtered off with suction
5. washwashed with isopropyl ether
6. dry with materialwith water and finally dried