Acetic Anhydride → N-(3-Bromo-4-fluorophenyl)acetamide

HRID 1059180Notes

Reaction equation

HRID 1059180 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[F:11].[C:12](OC(=O)C)(=[O:14])[CH3:13]>[Fe]>[Br:1][C:2]1[CH:7]=[C:6]([NH:8][C:12](=[O:14])[CH3:13])[CH:5]=[CH:4][C:3]=1[F:11]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 696992-Bromo-1-fluoro-4-nitrobenzene

Product 1

HCID 18668623N-(3-Bromo-4-fluorophenyl)acetamide

Reagents, catalysts & solvents 1

HCID 23925IronCatalyst

Procedure

By the reaction in the same manner as in Example 33-(i) using 2-bromo-1-fluoro-4-nitrobenzene (2.27 g), iron powder (2.90 g) and acetic anhydride (2.0 ml), the title compound (2.28 g) was obtained as colorless powder crystals.

Sources & evidence

ORD record
ord-057f7f76f0ed40d791171240f6b53df6
Source dataset
uspto-grants-2003_02
Patent number
US06518257B1

Reaction notes

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