Sulfamide → HCID 11000095, compound

HRID 1059346Notes

Reaction equation

HRID 1059346 reaction equation
[NH2:1][CH:2]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:4][CH2:3]1.[S:15](N)([NH2:18])(=[O:17])=[O:16]>C(COC)OC>[CH2:8]([N:5]1[CH2:6][CH2:7][CH:2]([NH:1][S:15]([NH2:18])(=[O:17])=[O:16])[CH2:3][CH2:4]1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 82267SulfamideHCID 4158521-Benzyl-4-piperidylamine

Product 1

HCID 11000095HCID 11000095, compoundYield 105.7%

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Conditions

Temperature
100 °C

Procedure

To a solution of 3.0 g of 4-amino-1-benzylpiperidine in dimethoxyethane (20 ml) was added 1.35 g of sulfamide. The resulting mixture was stirred at 100° C. for 10 minutes and then reacted at 130° C. for 1 hour. After distilling off the solvent under reduced pressure, 4.0 g of the title compound was obtained as a brown oily substance.

Workup

  1. customreacted at 130° C. for 1 hour
  2. distillationAfter distilling off the solvent under reduced pressure

Sources & evidence

ORD record
ord-2dd291900b634825b4c1f7ee5072c464
Source dataset
uspto-grants-2003_02
Patent number
US06518423B1

Reaction notes

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