反应详情

250 mg of 8-aminomethyl-10-methoxymethyl-10H-pyrazino-[2,3-b][1,4]benzothiazine was heated under reflux in 10 ml of ethyl formate for 3 hours. Then the reaction mixture was brought back to room temperature and distributed into an aqueous solution of ammonium chloride and ethyl acetate. The organic layer was extracted, washed with water and then dried over anhydrous sodium sulfate. After distilling off the solvent under reduced pressure, the crystals thus precipitated were filtered after adding diisopropyl ether. Thus 230 mg of the title compound was obtained as yellow crystals.

1. customwas brought back to room temperature
2. extractionThe organic layer was extracted
3. washwashed with water
4. dry with materialdried over anhydrous sodium sulfate
5. distillationAfter distilling off the solvent under reduced pressure
6. customthe crystals thus precipitated
7. filtrationwere filtered
8. additionafter adding diisopropyl ether