Benzenesulfonyl chloride → HCID 18630687, compound

HRID 1059537Notes

Reaction equation

HRID 1059537 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([N:7]2[CH:11]([CH:12]=[CH2:13])[CH2:10][N:9]([C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([C:20](=[NH:22])[NH2:21])[CH:15]=3)[C:8]2=[O:23])[CH2:3][CH2:2]1.[C:24]1([S:30](Cl)(=[O:32])=[O:31])[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.C(N(CC)CC)C>O1CCCC1>[C:24]1([S:30]([N:1]2[CH2:6][CH2:5][CH:4]([N:7]3[CH:11]([CH:12]=[CH2:13])[CH2:10][N:9]([C:14]4[CH:19]=[CH:18][CH:17]=[C:16]([C:20](=[NH:21])[NH2:22])[CH:15]=4)[C:8]3=[O:23])[CH2:3][CH2:2]2)(=[O:32])=[O:31])[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

Participants

5

Reactant 3

HCID 7369Benzenesulfonyl chlorideHCID 8471TriethylamineHCID 18630707HCID 18630707, compound

Product 1

HCID 18630687HCID 18630687, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In this case the title compound was prepared by sulfonylation of 1-(piperidin-4-yl)-3-(3-amidinophenyl)-5-ethenyl-2-imidazolidinone with phenylsulfonyl chloride in tetrahydrofuran with triethylamine folowed by amidine formation as described above; HRMS (M+H)+ calc. 454.191287, found 454.191418.

Sources & evidence

ORD record
ord-4fa2517ca90a4a93ab4780718647cac4
Source dataset
uspto-grants-2003_02
Patent number
US06521614B1

Reaction notes

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