Tetrahydrofuran → HCID 10216479, compound

HRID 1059841Notes

Reaction equation

HRID 1059841 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([N:11]([S:25]([C:28]3[CH:33]=[C:32]([O:34][CH3:35])[C:31]([O:36][CH3:37])=[C:30]([O:38][CH3:39])[CH:29]=3)(=[O:27])=[O:26])[CH2:12][CH2:13][NH:14]C(=O)OCC3C=CC=CC=3)=[CH:8][CH:9]=2)[CH:4]=[CH:3]1.C1COCC1.[H][H]>CO.[Pd]>[NH2:14][CH2:13][CH2:12][N:11]([C:7]1[CH:6]=[C:5]2[C:10](=[CH:9][CH:8]=1)[N:2]([CH3:1])[CH:3]=[CH:4]2)[S:25]([C:28]1[CH:29]=[C:30]([O:38][CH3:39])[C:31]([O:36][CH3:37])=[C:32]([O:34][CH3:35])[CH:33]=1)(=[O:27])=[O:26]

Participants

6

Reactant 3

HCID 8028TetrahydrofuranHCID 22344723HCID 22344723, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 10216479HCID 10216479, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of Example 51A in methanol:THF (1 mL:1 mL) was treated with 10% palladium on carbon (30 mg), stirred under with hydrogen (1 atm) for 2 hours, filtered through diatomaceous earth (Celite®), and concentrated to provide the desired compound.

Workup

  1. filtrationfiltered through diatomaceous earth (Celite®)
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-fcafb012ce484379a6fc066689d3ece9
Source dataset
uspto-grants-2003_02
Patent number
US06521658B1

Reaction notes

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