Sodium Sulfite → HCID 102438505, compound

HRID 1059853Notes

Reaction equation

HRID 1059853 reaction equation
[O-]S([O-])=O.[Na+:5].[Na+].C([O-])(O)=O.[Na+].[CH3:12][O:13][C:14]1[CH:19]=[CH:18][C:17]([S:20](Cl)(=[O:22])=[O:21])=[CH:16][C:15]=1[N+:24]([O-:26])=[O:25]>O.CC(C)=O>[CH3:12][O:13][C:14]1[CH:19]=[CH:18][C:17]([S:20]([O-:22])=[O:21])=[CH:16][C:15]=1[N+:24]([O-:26])=[O:25].[Na+:5]

Participants

6

Reactant 3

HCID 24437Sodium SulfiteHCID 89600Benzenesulfonyl chloride, 4-methoxy-3-nitro-HCID 516892Sodium Bicarbonate

Product 1

HCID 102438505HCID 102438505, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 962WaterSolvent

Conditions

Temperature
50 °C

Procedure

A solution of Na2SO3 (400 mg, 3.2 mmol) and NaHCO3 (270 mg, 3.2 mmol) in H2O (10 mL) was treated slowly with a solution of 4-methoxy-3-nitrobenzenesulfonyl chloride (400 mg, 1.6 mmol) in acetone (3 mL), heated to 50° C. for 2 hours, cooled to room temperature, and washed with dichloromethane. The aqueous wash was filtered through cotton, lyophilized, suspended in methanol, filtered, concentrated, and dried under vacuum to provide the desired product.

Workup

  1. temperaturecooled to room temperature
  2. washwashed with dichloromethane
  3. washThe aqueous wash
  4. filtrationwas filtered through cotton
  5. filtrationfiltered
  6. concentrationconcentrated
  7. customdried under vacuum

Sources & evidence

ORD record
ord-0be33b99fca249d8bcabe0dbf8239a43
Source dataset
uspto-grants-2003_02
Patent number
US06521658B1

Reaction notes

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