HCID 54513511, compound → 4-Isopropyloxy-2-methylpyridine

HRID 1059869Notes

Reaction equation

HRID 1059869 reaction equation
[CH:1]([O:4][C:5]1[CH:10]=[CH:9][N+:8]([O-])=[C:7]([CH3:12])[CH:6]=1)([CH3:3])[CH3:2]>CC(O)C.[Ni]>[CH:1]([O:4][C:5]1[CH:10]=[CH:9][N:8]=[C:7]([CH3:12])[CH:6]=1)([CH3:3])[CH3:2]

Participants

4

Reactant 1

HCID 54513511HCID 54513511, compound

Product 1

HCID 186675734-Isopropyloxy-2-methylpyridineYield 78.7%

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 3776IsopropanolSolvent

Procedure

A suspension of 4-isopropyloxy-2-methylpyridine N-oxide (0.78 g) in 2-propanol (10 ml) was hydrogenated over Raney-nickel (50% suspension in water, 1 ml) under a hydrogen atmosphere for 48 hours. The catalyst was filtered off, and the filtrate was evaporated under reduced pressure to give 4-isopropyloxy-2-methylpyridine (555 mg).

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate was evaporated under reduced pressure

Sources & evidence

ORD record
ord-5308d304416e473dab3b9bf7ec755edf
Source dataset
uspto-grants-2003_02
Patent number
US06521643B1

Reaction notes

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