Dimethylamine → HCID 818140, compound

HRID 1059871Notes

Reaction equation

[CH3:1][NH:2][CH3:3].[CH3:4][C:5]1[CH:10]=C([N+]([O-])=O)[CH:8]=[CH:7][N+:6]=1[O-:14].O1CCC[CH2:16]1>>[CH3:1][N:2]([CH3:16])[C:3]1[CH:8]=[CH:7][N+:6]([O-:14])=[C:5]([CH3:10])[CH:4]=1

Participants

Reactant 3

HCID 674Dimethylamine

HCID 8028Tetrahydrofuran

HCID 95291Pyridine, 2-methyl-4-nitro-, 1-oxide

Product 1

HCID 818140HCID 818140, compound

Conditions

Temperature: 60 °C

Procedure

To a solution of dimethylamine in tetrahydrofuran (2M, 20 ml) was added 2-methyl-4-nitropyridine N-oxide (3.08 g), and the mixture was stirred at 60° C. for 8 hours. The residue was evaporated under reduced pressure and purified by column chromatography (silica gel 75 g, 0 to 10% methanol in dichloromethane) to give 4-dimethylamino-2-methylpyridine N-oxide (1.76 g).

Workup

customThe residue was evaporated under reduced pressure
custompurified by column chromatography (silica gel 75 g, 0 to 10% methanol in dichloromethane)

Sources & evidence

ORD record: ord-1ab8b8ce398b454fb70ac04085bbf341
Source dataset: uspto-grants-2003_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06521643B1

Reaction notes

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