HCID 818140, compound → HCID 585150, compound

HRID 1059872Notes

Reaction equation

HRID 1059872 reaction equation
[CH3:1][N:2]([CH3:11])[C:3]1[CH:8]=[CH:7][N+:6]([O-])=[C:5]([CH3:10])[CH:4]=1>CC(O)C.[Ni]>[CH3:1][N:2]([CH3:11])[C:3]1[CH:8]=[CH:7][N:6]=[C:5]([CH3:10])[CH:4]=1

Participants

4

Reactant 1

HCID 818140HCID 818140, compound

Product 1

HCID 585150HCID 585150, compoundYield 90.3%

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 3776IsopropanolSolvent

Procedure

A suspension of 4-dimethylamino-2-methylpyridine N-oxide (1.67 g) in 2-propanol (15 ml) was hydrogenated over Raney-nickel (50% suspension in water, 1 ml) under a hydrogen atmosphere for 3 hours. The catalyst was filtered off, and the filtrate was evaporated under reduced pressure to give 4-dimethylamino-2-methylpyridine (1.35 g).

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate was evaporated under reduced pressure

Sources & evidence

ORD record
ord-dc177305caf64e4f9802646abf70b1f1
Source dataset
uspto-grants-2003_02
Patent number
US06521643B1

Reaction notes

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