Diisopropyl Ether → N-(3-(4-methoxypyridin-2-yl)phenyl)-N'-benzoylthiourea

HRID 1059997Notes

Reaction equation

HRID 1059997 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([C:9]2[CH:10]=[C:11]([CH:13]=[CH:14][CH:15]=2)[NH2:12])[CH:4]=1.[C:16]([N:24]=[C:25]=[S:26])(=[O:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.C(OC(C)C)(C)C>CC(C)=O>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([C:9]2[CH:10]=[C:11]([NH:12][C:25]([NH:24][C:16](=[O:23])[C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)=[S:26])[CH:13]=[CH:14][CH:15]=2)[CH:4]=1

Participants

5

Reactant 3

HCID 7914Diisopropyl EtherHCID 68284Benzoyl isothiocyanateHCID 186674893-(4-Methoxypyridin-2-yl)aniline

Product 1

HCID 18667595N-(3-(4-methoxypyridin-2-yl)phenyl)-N'-benzoylthiourea

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a suspension of 3-(4-methoxypyridin-2-yl)aniline (357 mg) in acetone (5 ml) was added benzoyl isothiocyanate (0.252 ml), and the mixture was stirred at ambient temperature for 1 hour. To the reaction mixture was added diisopropyl ether, and the precipitate was collected by filtration and dried to give N-(3-(4-methoxypyridin-2-yl)phenyl)-N′-benzoylthiourea (462 mg).

Workup

  1. filtrationthe precipitate was collected by filtration
  2. customdried

Sources & evidence

ORD record
ord-db84ccf3d1f047baa17bc9a0eea5c3a5
Source dataset
uspto-grants-2003_02
Patent number
US06521643B1

Reaction notes

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