反应详情

To a solution of 1-fluoro-4-(4-methoxypyridin-2-yl)-2-nitrobenzene (200 mg) and triethylamine (0.135 ml) in tetrahydrofuran (2 ml) was added aniline (2 ml). The mixture was stirred under reflux for 6 hours and evaporated under reduced pressure. The residue was dissolved in ethyl acetate and washed with water and brine, dried over magnesium sulfate and evaporated under reduced pressure. The precipitate was triturated with diisopropyl ether, collected by filtration and dried to give 4-(4-methoxypyridin-2-yl)-2-nitro-N-phenylaniline (235 mg).

1. temperatureunder reflux for 6 hours
2. customevaporated under reduced pressure
3. dissolutionThe residue was dissolved in ethyl acetate
4. washwashed with water and brine
5. dry with materialdried over magnesium sulfate
6. customevaporated under reduced pressure
7. customThe precipitate was triturated with diisopropyl ether
8. filtrationcollected by filtration
9. customdried