Hydrochloric Acid → N-[(5-Isoquinolyl)sulfonyl]-1,4-xylylenediamine

HRID 10601Notes

Reaction equation

HRID 10601 reaction equation
C(OC([NH:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][NH:17][S:18]([C:21]2[CH:30]=[CH:29][CH:28]=[C:27]3[C:22]=2[CH:23]=[CH:24][N:25]=[CH:26]3)(=[O:20])=[O:19])=[CH:12][CH:11]=1)=O)(C)(C)C.Cl>CO>[CH:26]1[C:27]2[C:22](=[C:21]([S:18]([NH:17][CH2:16][C:13]3[CH:14]=[CH:15][C:10]([CH2:9][NH2:8])=[CH:11][CH:12]=3)(=[O:19])=[O:20])[CH:30]=[CH:29][CH:28]=2)[CH:23]=[CH:24][N:25]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69523966N-(tert-butoxycarbonyl)-N'-[(5-isoquinolyl)sulfonyl]-1,4-xylylenediamine

Product 1

HCID 69524387N-[(5-Isoquinolyl)sulfonyl]-1,4-xylylenediamineYield 80.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

According to Reference Example 5, Step C, a reaction was performed by using Intermediate 60 (6 g) and 10% hydrogen chloride in methanol (20 ml) to obtain the title compound (3.7 g).

Sources & evidence

ORD record
ord-91463f1115d148529346c0f15f210d9b
Source dataset
uspto-grants-2006_08
Patent number
US07094789B2

Reaction notes

Loading…