Methanesulfonic Acid → HCID 18630836, compound

HRID 1060187Notes

Reaction equation

HRID 1060187 reaction equation
C1(C[N:8]2[CH:12]([CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH2:11][C:10](=[O:20])[CH2:9]2)C=CC=CC=1.[CH3:21][S:22]([OH:25])(=[O:24])=[O:23]>C1COCC1.[Pd]>[CH3:21][S:22]([OH:25])(=[O:24])=[O:23].[C:14]1([CH2:13][CH:12]2[NH:8][CH2:9][C:10](=[O:20])[CH2:11]2)[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

Participants

5

Reactant 2

HCID 6395Methanesulfonic AcidHCID 18630842HCID 18630842, compound

Product 1

HCID 18630836HCID 18630836, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of intermediate 22 (0.027 mol) and CH3SO3H (0.03 mol) in THF (200 ml) was hydrogenated with palladium on activated carbon (10%, 2 g) as a catalyst. After uptake of hydrogen, the catalyst was filtered off, yielding (±)-5-(phenylmethyl)-3-pyrrolidinone methanesulfonate(1:1) (intermediate 23).

Workup

  1. filtrationAfter uptake of hydrogen, the catalyst was filtered off

Sources & evidence

ORD record
ord-a70eccdbb5d94013bb346706a8d116b8
Source dataset
uspto-grants-2003_02
Patent number
US06521621B1

Reaction notes

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