反应详情

To a flask charged with 2,2-difluoro-2-phenylacetic acid (0.8 g, 5.06 mmol), as prepared in the preceding step, under argon in an ice-bath was added oxalyl chloride (5 mL), and the reaction mixture stirred for 15 min. A solution of dimethylformamide (DMF) (37 mg, 0.506 mmol) in DCM (0.5 mL) was added. After 2 hours, the ice-bath was removed, and the mixture continued to stir for 1 hour. The solvents were evaporated, DCM was added, and then evaporated in vacuo giving the title compound (0.88 g, 98% yield), that was used immediately without further purification.

1. customas prepared in the preceding step, under argon in an ice-bath
2. waitAfter 2 hours
3. customthe ice-bath was removed
4. stirringto stir for 1 hour
5. customThe solvents were evaporated
6. additionDCM was added
7. customevaporated in vacuo