Pyrrolidine → 4-Fluoro-N-(4-methoxy-7-pyrrolidin-1-yl-benzothiazol-2-yl)-benzamide

HRID 1060314노트

반응식

HRID 1060314 반응식
BrC1C=CC(OC)=C([N+]([O-])=O)C=1.N1CCCC1.[F:18][C:19]1[CH:44]=[CH:43][C:22]([C:23]([NH:25][C:26]2[S:27][C:28]3[C:34]([N:35]4[CH2:40][CH2:39]O[CH2:37][CH2:36]4)=[CH:33][CH:32]=[C:31]([O:41][CH3:42])[C:29]=3[N:30]=2)=[O:24])=[CH:21][CH:20]=1>>[F:18][C:19]1[CH:20]=[CH:21][C:22]([C:23]([NH:25][C:26]2[S:27][C:28]3[C:34]([N:35]4[CH2:36][CH2:37][CH2:39][CH2:40]4)=[CH:33][CH:32]=[C:31]([O:41][CH3:42])[C:29]=3[N:30]=2)=[O:24])=[CH:43][CH:44]=1

참가 물질

4

반응물 3

HCID 31268PyrrolidineHCID 1185334-Bromo-2-nitroanisoleHCID 102002144-fluoro-N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-benzamide

생성물 1

HCID 222831854-Fluoro-N-(4-methoxy-7-pyrrolidin-1-yl-benzothiazol-2-yl)-benzamide

실험 절차

The title compound was prepared strarting from 4-bromo-1-methoxy-2-nitro-benzene and pyrrolidine as described for 4-fluoro-N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-benzamide (Example 275) and obtained as a light brown solid in about 10% overall yield, MS: m/e=372 (M+H+).

후처리

  1. customobtained as a light brown solid in about 10% overall yield, MS

출처 및 근거

ORD 기록
ord-644b2ec8d65140fa9ef505b98277d165
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06521754B2

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