Potassium Carbonate → HCID 22645641, compound

HRID 1060794Notes

Reaction equation

HRID 1060794 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:10]([F:13])([F:12])[F:11])[CH:5]=[C:6]([Cl:9])[C:7]=1F.[F:14][C:15]1[CH:23]=[C:22]2[C:18]([CH:19]=[CH:20][NH:21]2)=[CH:17][CH:16]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O.O>[Cl:1][C:2]1[CH:3]=[C:4]([C:10]([F:13])([F:12])[F:11])[CH:5]=[C:6]([Cl:9])[C:7]=1[N:21]1[C:22]2[C:18](=[CH:17][CH:16]=[C:15]([F:14])[CH:23]=2)[CH:19]=[CH:20]1

Participants

6

Reactant 3

HCID 11430Potassium CarbonateHCID 157026Benzene, 1,3-dichloro-2-fluoro-5-(trifluoromethyl)-HCID 3512786-Fluoroindole

Product 1

HCID 22645641HCID 22645641, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Conditions

Temperature
90 °C

Procedure

To a solution of 3,5-dichloro-4-fluorobenzotrifluoride (34.5 g) in dimethylformamide (250 ml) was added 6-fluoroindole (34.5 g) and potassium carbonate (20.4 g). The mixture was heated at 90° C. for 6 hours and then left to stir for 16 hours at room temperature. The reaction was diluted with water (1000 ml) and extracted with hexane (1000 ml). The organic fraction was separated and evaporated to dryness to give the title compound as a colourless liquid. δ(CDCl3): 7.80 (2H,s), 7.62 (1H,dd), 7.20 (1H,d), 6.96 (1H,dt), 6.76 (1H,d), 6.62 (1H,dd.

Workup

  1. waitleft
  2. extractionextracted with hexane (1000 ml)
  3. customThe organic fraction was separated
  4. customevaporated to dryness

Sources & evidence

ORD record
ord-72df8882cd0c47d09a78dc8f1d34ceda
Source dataset
uspto-grants-2003_02
Patent number
US06525079B2

Reaction notes

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