Potassium Carbonate → HCID 22645642, compound

HRID 1060795Notes

Reaction equation

HRID 1060795 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:10]([F:13])([F:12])[F:11])[CH:5]=[C:6]([Cl:9])[C:7]=1F.[NH2:14][C:15]1[N:19]=[CH:18][NH:17][N:16]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O.O>[NH2:14][C:15]1[N:16]([C:7]2[C:2]([Cl:1])=[CH:3][C:4]([C:10]([F:13])([F:12])[F:11])=[CH:5][C:6]=2[Cl:9])[N:17]=[CH:18][N:19]=1

Participants

6

Reactant 3

HCID 11430Potassium CarbonateHCID 157026Benzene, 1,3-dichloro-2-fluoro-5-(trifluoromethyl)-HCID 178418311HCID 178418311, compound

Product 1

HCID 22645642HCID 22645642, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Conditions

Temperature
100 °C

Procedure

To a solution of 3,5-dichloro-4-fluorobenzotrifluoride (1.0 g) in dimethylformamide (5 ml) was added 3-amino-1,2,4-triazole (360 mg) and potassium carbonate (296 mg), the mixture was heated at 100° C. for 2hrs. The reaction was cooled to room temperature, diluted with water (100 mL) and extracted with ether (100 ml). The organic extracts were evaporated to dryness to give the title compounds as pale yellow crystals.

Workup

  1. temperatureThe reaction was cooled to room temperature
  2. extractionextracted with ether (100 ml)
  3. customThe organic extracts were evaporated to dryness

Sources & evidence

ORD record
ord-aaa288695b1b4881a2ad29fe39324a17
Source dataset
uspto-grants-2003_02
Patent number
US06525079B2

Reaction notes

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